A former child actress, Alison Pill began her career at age twelve, appearing in numerous films and television series. She transitioned to adult roles and her breakthrough came with the television series The Book of Daniel (2006). That same year, she was nominated for a Tony Award for Best Featured Actress in a Play for her performance in The Lieutenant of Inishmore (2006).
Pill had prominent roles in the films Confessions of a Teenage Drama Queen (2004), Milk (2008), Scott Pilgrim vs. the World (2010) and Midnight in Paris (2011), and the television series In Treatment (2009), The Pillars of the Earth (2010) and The Newsroom (2012–14).