Kaya Jackson
voices Ada Twist
Nicholas Crovetti
voices Iggy Peck
Candace Kozak
voices Rosie Revere
Susan Kelechi Watson
voices Mom Twist
Taye Diggs
voices Dad Twist
Corey J. Laramore
voices Benny B
Fortune Feimster
voices Rosie's Mom
Paul F. Tompkins
voices Iggy's Dad
Margo Martindale
voices Great Aunt Rose
Loretta Devine
voices Great Aunt Bernice
Yonas Kibreab
voices Miguel
Mykal-Michelle Harris
voices London
Kate Micucci
voices Iggy's Mom
Carolyn Hennesy
voices Marian
Krizia Bajos
voices B.R.I.
Dashiell McGaha-Schletter
voices Simon
Alex Jayne Go
voices Sawa
Ali Wong
voices Cherry Chen
Lyriq Bent
voices Beck
Nia Madison Thompson
voices Bee-Bee
Nicole Byer
voices Professor Flowerbomb
George Takei
voices Sensei Dave
Yvette Nicole Brown
voices Auntie Nadine
Justice Reign Killebrew
voices Nassan
Taye Diggs
voices Dadbot
Sheryl Lee Ralph
voices Glam-Ma
Taye Diggs
voices Alien
Paul F. Tompkins
voices Monster
Taye Diggs
voices Director
Fortune Feimster
voices Alien
Nicole Byer
voices Grumpy Dragon One
Nicole Byer
voices Newscaster
Taye Diggs
voices DJ
Paul F. Tompkins
voices Howler
Loretta Devine
voices Pixel-Bernice
Krizia Bajos
voices Dr. Letcia Luna
Keith David
voices Pop-Pop
Roxana Ortega
voices Clara
Jaden Rogers
voices Dre
Artemis Totolos
voices Charlie
Bodhi Del Rosario
voices Gabe
Olivia Perez
voices Violeta
Iona Morris
voices Grandma
Paul F. Tompkins
voices Announcer
Guillermo Diaz
voices Jiu Jitsu Joe
Táta Vega
voices Jiu Jitsu Joe's Mom
Gillian Jacobs
voices Miss Lila Greer
Hari Kondabolu
voices Principal Rahul
Cassidy Naber
voices Fakhira
Corey J. Laramore
voices Supercomputer
Imani Hanson
voices Ruben
Audrey Bennett
voices Alie
Jersey Sky Morehead
voices Knatokie
Roxana Ortega
voices Phone Operator
Nnedi Okorafor
voices Alex Akerele
G.K. Bowes
voices Summer Gauthier
Judah Edwards
voices Young Dad Twist
Yonas Kibreab
voices Futuristic Kid #1