Guest Stars Andrew Buchan as Matt Hancock Ophelia Lovibond as Carrie Symonds Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison Philip Buck as Martin Reynolds Derek Barr as Lee Cain Jimmy Livingstone as Chris Whitty Shri Patel as Rishi Sunak Simon Paisley Day as Dominic Cummings James Corrigan as Isaac Levido Simon Lowe as James Slack Ravin J. Ganatra as Roshan Wasim Zakir as Amir Hamdi Salima Saxton as Teena Joe Bannister as Jack Doyle Nina Beagley as Sally Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Justin Edwards as Mark Sedwill Helen Monks as Jodie Heather Peace as Mary Wakefield Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Tim Harford as Himself Isabella Javor as Lara Greta Bellamacina as Cleo Watson Ruth Redman as Yvonne Doyle Olivier Huband as Jamie Rina Mahoney as Julie Kate Lawson as Herself Richard Vadon as Himself Adrian Harris as Duncan Selbie Albin Calderon as Manny Anna Calder-Marshall as Charlotte Ruth Alexander Rubin as Herself Noel White as Richard Horton Zoë Aldrich as Sarah Gilbert Orson Berthier Ronald as Cedd Hiten Patel as Downing Street Security Guard Sam Dutton as DoH Official Josephina Holroyd as Andrea Belinda Lang as Josephine Patrick Grant as Cookson and Clegg Simon Kunz as Andrew Mills Henry Garrett as Archie Bland Tim Delap as Dominic Raab Tim Berrington as John Newton Brooke Havana Bailey as Jogger Chris Patten as Robert Ajay Chabra as Jin Sahota David Shaw Parker as Sir Paul Nurse Anthony Shuster as Matthew Weaver Max Dowler as Guardian Editor Elen Rhys as Physio - Janet Jasmine Hyde as Pippa Crerar Kate Fahy as Clare Edwards Tabeer Tahir as Aysha Isabella Farchy as Deliotte Worker Sam Lupton as Robert Jenrick Tom Slattery as Police Media Officer Nicola McRoy as Kate Bingham Matilda Mosse-Williams as Pippa's Child Robin Lees as Themselves Frida Mosse-Williams as Pippa's Child David Kennaway as Tim Horlick Andy Commins as Bluebell Woods Photographer Jeremy Armstrong as Himself Emily Bowyer as Emily Gareth Crickmer as Dave Marc Richardson as Jens Wiechers Adam Jackson-Smith as Nick Hopkins Gavin Kitchen as Dave Edwards Dan March as Jesse Norman Shahid Ahmed as Factory Manager Russell Kilmister as Peter Richard Teverson as John Penrose Simon Hepworth as Grant Shapps Johanne Murdock as Dido Harding Chloe Okura as Midwife - Hirut