Guest Stars Andrew Buchan as Matt Hancock Ophelia Lovibond as Carrie Symonds Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison James Corrigan as Isaac Levido Shri Patel as Rishi Sunak Philip Buck as Martin Reynolds Simon Paisley Day as Dominic Cummings Derek Barr as Lee Cain Jimmy Livingstone as Chris Whitty Simon Lowe as James Slack Justin Edwards as Mark Sedwill Lee Comley as Ben Michael Colgan as Gabriel Milland Joe Bannister as Jack Doyle Tom Andrews as Tom Armstrong Ben Lloyd-Hughes as Ben Gascoigne Wasim Zakir as Amir Hamdi Salima Saxton as Teena Heather Peace as Mary Wakefield Albin Calderon as Manny Olivier Huband as Jamie Greta Bellamacina as Cleo Watson Isabella Javor as Lara Orson Berthier Ronald as Cedd Andrew Ehrensperger as Theo Daniel Marot as Milo Sam Dutton as DoH Official Hiten Patel as Downing Street Security Guard Simon Treves as NHS Medical Director Angela Wynter as Sarah Boateng Patrick Grant as Cookson and Clegg Simon Kunz as Andrew Mills Jane Bertish as Claire Green Tim Berrington as John Newton Lindsey Riding as Nurse Rizwan Khan as Downing Street Doctor Hannah Figgens as Landermeads Carer Caroline Bowers as Landermeads Carer Georgia Bowers as Landermeads Carer Edward Ofosu-Osei as Tony Boateng Bob Hopkinson as Resident Olivia-Rose Burton as Cassia Ajay Chabra as Jin Sahota Keshini Misha as Rubaya Mark Lewis as Steven Green Jaeceena Anderson as Asale Child Darryl Mundoma as Asale Child Edward Cole as Durham Police Officer Angela Carruthers as Factory Manager Gilly Daniels as Resident Timothy Edward Bartholomew as Robert Jessica Hof as DoH Official Keshav Shree as Dentist Sandra Voe as Morag Michelle Asante as Grace Gbolahan Obisesan as Frank James McNicholas as Deloitte Advisor Freddie Meredith as Adam Green Carly Bawden as Jo Green Ross Hatt as Norwich Doctor