Guest Stars Andrew Buchan as Matt Hancock Ophelia Lovibond as Carrie Symonds Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison Philip Buck as Martin Reynolds Simon Paisley Day as Dominic Cummings James Corrigan as Isaac Levido Derek Barr as Lee Cain Shri Patel as Rishi Sunak Jimmy Livingstone as Chris Whitty Lee Comley as Ben Wasim Zakir as Amir Hamdi Ravin J. Ganatra as Roshan Salima Saxton as Teena Ben Lloyd-Hughes as Ben Gascoigne Justin Edwards as Mark Sedwill Roisin Rae as Sally Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Helen Monks as Jodie Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Adrian Harris as Duncan Selbie Rina Mahoney as Julie Olivier Huband as Jamie Ruth Redman as Yvonne Doyle Kate Lawson as Herself Richard Vadon as Himself Albin Calderon as Manny Tim Harford as Himself Anna Calder-Marshall as Charlotte Sam Phillips as Rob Anthony Howell as Neil Ferguson Julia Farino as Amanda Pritchard Josephina Holroyd as Andrea Robert Heard as Ben Warner Tom Nguyen as Jonathan Van Tam Simon Treves as NHS Medical Director Sam Rathore as Sami Martin Fisher as Joe Rick Bacon as Graham Medley Tim Wallers as Simon Stevens Angela Wynter as Sarah Boateng Jane Bertish as Claire Green Daniel Kobbina as Steve Jim Whelan as Des's Dad Andrea Waite as Sue Mickey Thompson as Des Bob Hopkinson as Resident Edward Ofosu-Osei as Tony Boateng Georgia Bowers as Landermeads Carer Caroline Bowers as Landermeads Carer Hannah Figgens as Landermeads Carer Michael Amariah as Mr Ojo's Son Mark Lewis as Steven Green Gala Gordon as Lizzie Christopher D. Grace as Marc Warner Shelley MacDonald as Imam Euan Macnaughton as Public Health England, Medical Advisor Jen Lim as Nurse Simon Molloy as Valerie's Dad Helen Ugwu as Tom's Wife Mary Greencroft as Brian's Wife Adam Jawed as Zulfi India Startford as Landermeads Carer Matt Weyland as Meag Laura June Hudson as Resident Ros Heath as Landermeads Manager Tony Timberlake as Doctor Bindni Karia as PHE Office Daniel Jack as Young Boris Johnson Jo McInnes as Sonja Adwoa Akoto as Sam Amy Shindler as Valerie April Kelly as Grange Head Office John Alastair as Army Colonel Damian Quinn as MHA Manager