Guest Stars Andrew Buchan as Matt Hancock Ophelia Lovibond as Carrie Symonds Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison James Corrigan as Isaac Levido Simon Paisley Day as Dominic Cummings Jimmy Livingstone as Chris Whitty Shri Patel as Rishi Sunak Philip Buck as Martin Reynolds Derek Barr as Lee Cain Simon Lowe as James Slack Joe Bannister as Jack Doyle Ben Lloyd-Hughes as Ben Gascoigne Lee Comley as Ben Ravin J. Ganatra as Roshan Roisin Rae as Sally Heather Peace as Mary Wakefield Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Ruth Redman as Yvonne Doyle Olivier Huband as Jamie Richard Vadon as Himself Greta Bellamacina as Cleo Watson Isabella Javor as Lara Kate Lawson as Herself Tim Harford as Himself Adrian Harris as Duncan Selbie Anna Calder-Marshall as Charlotte Anthony Howell as Neil Ferguson Sam Phillips as Rob Julia Farino as Amanda Pritchard Sam Rathore as Sami Tom Nguyen as Jonathan Van Tam Rick Bacon as Graham Medley Simon Treves as NHS Medical Director Noel White as Richard Horton Daniel Marot as Milo Martin Fisher as Joe Andrew Ehrensperger as Theo Ruth Alexander Rubin as Herself Zoë Aldrich as Sarah Gilbert Robert Heard as Ben Warner Belinda Lang as Josephine Gwynne McElveen as Dream Woman John L. Armstrong as Procurement Manager Sam Patrick as John Edmunds Greg Haiste as Peter Horby Christopher Reynalds as Michael Gove Charles Dance as Max Hastings Oli Higginson as Saul Jade Leonce as Mandy Jimmy Cosgrove as Public Health England Worker Pat Brocklehurst as Resident Mike Truelove as Steve Walsh Dr Nathalie MacDermott as Herself Natasha Lewis as NHS Rep Ngee Kiang Goh as Gabriel Leung Benjamin Wok as Li Wen Liang Louise Morell as Teresa Lambe Doug Colling as Ben Reynah Rita as Munira Mirza Robin Morgan as Colin Kuran Dohil as Sonia Khan James Allen as Family Court Judge Mark Hampton as George Gao Baely Saunders as Journalist